Buy 7 Keto Dhea
7-Ketodehydroepiandrosterone (7-keto-DHEA,7-oxo-DHEA), also known as 7-oxoprasterone, is a prohormone produced by metabolism of the prohormone dehydroepiandrosterone (DHEA).[1]
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7-oxodehydroepiandrosterone (7-oxo DHEA and more commonly known as the brand name 7-keto) is one of three oxygenated metabolites of dehydroepiandrosterone, and these three oxygenated metabolites interconvert with one another but do not convert back into parent DHEA; 7-keto supplementation is a way to get these three oxygenated metabolites without using DHEA supplementation, and DHEA may form androgenic and estrogenic hormones via an alternate metabolic pathway (which 7-keto does not participate in).
7-keto supplementation is mostly known to not be hormonal; it can interact with steroid metabolism but the exact manner in which it does it not fully elucidated. It does appear to have anti-cortisol mechanisms as the enzymes that activate cortisol (from the relatively inactive precursors of cortisone and corticosterone) are the same that interconvert these oxygenated metabolites. Although it appears to be anti-cortisol by its mechanisms, there is insufficient evidence to support these mechanisms in the body following oral supplementation.
Studies using 7-keto supplementation tend to note an increased metabolic rate later on during a caloric restriction period (which is secondary to reducing the rate of metabolic rate decline associated with dieting, and becoming a relative increase) although the quantity of data on this is pretty minimal if we exclude studies with possible conflicts of interest or those that use 7-keto alongside a multitude of supplements.
7-keto-DHEA (3β-hydroxy-androst-5-ene-7,17-dione) is included in section S1 of the World Antidoping Agency (WADA) List of Prohibited Substances. The detection of its misuse in sports needs special attention, since it is naturally present in urine samples. The main goal of this study is to investigate the in vivo metabolism of 7-keto-DHEA after a single administration to healthy volunteers and to better describe the relationship between arimistane (androst-5-ene-7,17-dione) and 7-keto-DHEA after the application of the common routine procedures to detect anabolic steroids in WADA accredited antidoping laboratories. Free, glucuro-, and sulpho-conjugated steroids extracted from urine samples obtained before and after the administration of 7-keto-DHEA were analyzed by different gas chromatographic (GC)-mass spectrometric (MS) techniques. Gas chromatography coupled to tandem MS to study the effect on the endogenous steroid profile, coupled to isotope ratio mass spectrometry (IRMS) to investigate the potential formation of androgens derived from DHEA and coupled to high resolution accurate mass spectrometry (HRMS) to investigate new diagnostic metabolites. The analysis by IRMS confirmed that there is no formation of DHEA from 7-keto-DHEA. Ten proposed metabolites, not previously reported, were described. These include reduced and hydroxylated structures that are not considered part of the steroid profile in antidoping analyses. They showed considerable responses in all fractions analyzed. Some deoxidation reactions (including arimistane formation) were found and most probably can be linked to the sample preparation or instrumental analysis. This is important when interpreting the results after the application of procedures to detect steroids in urine currently used in antidoping laboratories. 7-keto-DHEA metabolism in humans for antidoping purposes was studied and unexpected results were found. This could lead to a misinterpretation of the data, depending on the procedure applied and the analytical instrumentation used.
In a similar study in overweight people, researchers looked at the effects of a supplement containing 7-keto-DHEA combined with seven other ingredients thought to have an additive effect on 7-keto-DHEA (8).
Individual and mean ED50 values in g/kg (ethanol) or mg/kg (DHEA, 7-keto DHEA, chlordiazepoxide, RO15-4513, and rauwolscine) for decreases in response rate in ethanol - and food - maintained responding.
Effects of acute administration of DHEA (n=7) and 7-keto DHEA (n=9) in rats responding under a multiple schedule of food and ethanol presentation. Unfilled symbols represent response rate during the ethanol component, whereas filled symbols represent response rate during the food component. The dependent measures were response rate (response/min), blood ethanol concentration (mg/dl), and the ethanol dose presented (g/kg). The mean rate of responding for food was 46.42 5.43 responses/min during testing with DHEA and 49.14 8.48 responses/min during testing with 7-keto DHEA, whereas the mean rate of responding for ethanol was 13.95 3.56 responses/min and 12.97 3.97 responses/min, respectively. The numbers in parentheses indicate the number of subjects for that data point when it was less than 7 (DHEA) or 8 (7-keto DHEA) due to the elimination of responding in some subjects at the higher doses. Asterisks indicate significant differences from vehicle administration (control). The bracket in the top panel indicates that the main effect of DHEA dose was analyzed with the data for each reinforcer combined as the interaction was not significant. In the middle panel, all of the data points within the bracket were significantly different from vehicle (control).
DHEA (5-Dehydroepiandrosterone) is a natural steroid produced in the adrenal glands, the gonads and the brain. It is the most abundant circulating steroid in humans. A form of DHEA, 7-keto DHEA (3-acetyl-7-oxodehydroepiandosterone), is claimed to have fewer side effects. DHEA is involved in a range of biological effects and may cause some problematic hormonal side effects. The newer form (7-keto DHEA) may be safer, but research on its effectiveness and its side effects is extremely limited. DHEA supplementation may help with depression, but it has a long list of potential side effects and drug interactions. MHA cautions against use of DHEA, cautiously recommends 7-keto DHEA as an alternative to DHEA pending further testing, and counsels getting the help of a skilled health care practitioner, especially if using any other drugs or herbs.
7-keto-DHEA is a byproduct of DHEA. But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skin does not increase the level of steroid hormones in the blood. Thus, 7-keto DHEA deserves study to determine whether it has the same efficacy as DHEA without the hormonal side effects.
If you are considering taking or continuing to take DHEA or 7-keto DHEA, you should definitely consult with a skilled health care practitioner. It is critical to consult with your prescribing physician if you are taking any psychotropic medication.
Each consumer needs to make a risk-versus-reward decision about DHEA. MHA urges caution because the evidence of efficacy is weak and the potential side effects and drug interactions are significant. More study is needed before 7-keto DHEA can be recommended as an alternative, but it may be prudent to consider it prior to studies substantiating the claims being made, in order to reduce risk.
7-keto-dehydroepiandrosterone (7-keto-DHEA), also called 7-oxo-DHEA, is a metabolite of the steroid hormone precursor DHEA.1 DHEA, in the form of its sulfate conjugate (DHEA-S), is the most abundant steroid present in human blood and has generated interest as a potential therapeutic agent in age-related and other health conditions based on studies in preclinical models.23 However, DHEA is converted to androgens and estrogens, including testosterone and estradiol, and can result in sex steroid-associated side effects, such as polycystic ovaries and signs of masculinization in females.234 Thus, 7-keto-DHEA has arisen as a promising alternative to DHEA because metabolites of DHEA, including 7-keto-DHEA, may mediate some the biological functions and physiological and clinical benefits of DHEA.5 Importantly, unlike DHEA, 7-keto-DHEA is not converted into testosterone or estradiol.26
Like DHEA, 7-keto-DHEA is produced endogenously in the adrenal glands, gonads, brain, liver, and skin.57 Physiological (serum) levels of 7-keto-DHEA vary widely among individuals; however, they appear to be similar among men and women.8 In a 2007 study of 215 individuals without endocrine disorders (91 males and 124 females; aged 5-71 years), no significant differences in 7-keto-DHEA levels were observed between males and females.8 The overall mean (SD) and median of 7-keto-DHEA levels were 0.280 (0.39) nmol/L and 0.239 nmol/L, respectively.8
At puberty, the level of 7-keto-DHEA rapidly increases and plateaus until approximately 35 years of age8; it then decreases with increasing age.9 Because the level of 7-keto-DHEA is directly related to the level of DHEA, decreasing 7-keto-DHEA levels are likely a reflection of decreasing DHEA levels, which are also known to decrease with age.10 Therefore, it is believed that DHEA and 7-keto-DHEA supplementation may help the body maintain a more youthful state and may be beneficial to individuals with low levels of DHEA or 7-keto-DHEA.6
7-keto-DHEA is typically administered orally as an acetyl ester of 7-oxo-DHEA (3β-acetyl-7-oxo-DHEA or 7-oxo-dehydroepiandrosterone-3 acetate11 ); this form (also often referred to as 7-keto-DHEA) is less susceptible to oxidation than 7-keto-DHEA during manufacturing and storage.31213 After administration, the 7-oxo-DHEA acetyl ester is rapidly converted to 7-oxo-DHEA-sulfate (7-keto-DHEA-S) in a concentration proportional to the administered dose.614
7-keto-DHEA has been shown to promote weight loss and increase resting metabolic rate in people who are overweight.151617 In two placebo-controlled double-blind trials, participants who received 7-keto-DHEA acetyl ester lost significantly more weight than those who received placebo (2000 study: mean, -2.88 kg vs -0.97 kg, respectively; P=.0115 and 2002 study: mean, -2.15 kg vs -0.72 kg, respectively; P=.03816). 041b061a72