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Иван Мамаев
Иван Мамаев

Operation Research Ebook Free Download By Jk Sharmal EXCLUSIVE


Operation Research Ebook Free Download By Jk Sharmal >>> https://urlin.us/2tqNUR



Operation Research Ebook Free Download By Jk Sharmal EXCLUSIVE


Operations Research Theory And Application ,Sixth Edition by JK Sharma, PDF, was published in 2017 and uploaded for 300-level Administration, Social and Management science students of Modibbo Adama University of Technology (MAUTECH), offering MM307 course. This ebook can be downloaded for FREE online on this page. Operations Research Theory And Application ,Sixth Edition ebook can be used to learn Linear Programming, Linear Programming Model Formulation, Graphical Method, Simplex Method, Duality in Linear Programming, Dual Linear Programming Problem, Sensitivity Analysis, Integer Linear Programming, Goal Programming, Transportation Problem, Assignment Problem, Decision Theory, Decision Trees, Theory of Games, game theory, Project Management, Deterministic Inventory Control Models, Probabilistic Inventory Control Models, Queuing Theory, Replacement Models, Maintenance Models, Markov Chains, Simulation, Sequencing Problems, Information Theory, Dynamic Programming, Classical Optimization Methods, Non-Linear Programming Methods, Revised Simplex Method, Dual-Simplex Method, Bounded Variables Linear Programming Problem, Parametric Linear Programming.


Yang et al. [49] prepared highly effective nanoparticles for revealing colorectal cancer (CC) cells via a light-mediated mechanism; these cells are visible owing to the physical conjugation of alginate with folic acid-modified chitosan leading to the formation of nanoparticles with enhanced 5-aminolevulinic (5-ALA) release in the cell lysosome. The results displayed that the engineered nanoparticles were voluntarily endocytosed by the CC cells by the folate receptor-based endocytosis process. Subsequently, the charged 5-ALA was dispersed into the lysosome which was triggered by less desirability strength between the 5-ALA and chitosan through deprotonated alginate that gave rise to the gathering of protoporphyrin IX (PpIX) for photodynamic detection within the cells. As per this research, chitosan-based nanoparticles in combination with alginate and folic acid are tremendous vectors for the definite delivery of 5-ALA to the CC cells to enable endoscopic fluorescent detection. Cathepsin B (CB) is strongly associated with the metastatic process and is available in surplus in the pericellular areas where this process occurs; thus, CB is important for the detection of metastasis. Ryu et al. [50] designed a CB-sensitive nanoprobe (CB-CNP) comprising a self-satisfied CB-CNP with a fluorogenic peptide attached to the tumor-targeting glycol chitosan nanoparticles (CNPs) on its surface. The designed nanoprobe is a sphere with a diameter of 280 nm, with spherical structure and its fluorescence capacity was completely extinguished under the biological condition. The evaluation of the usability of CB-sensitive nanoprobe in three rat metastatic models demonstrated the potential of these nonoprobes in discriminating metastatic cells from healthy ones through non-invasive imaging. Hyaluronic acid (HA) is another biopolymeric material. This is a biocompatible, negatively charged glycosaminoglycan, and is one of the main constituents of the extracellular matrix [51, 52]. HA can bind to the CD44 receptor, which is mostly over articulated in various cancerous cells, through the receptor-linker interaction. Thus, HA-modified nanoparticles are intriguing for their use in the detection and cure of cancer [53,54,55]. Wang et al. [56], coated the surface of iron oxide nanoparticles (IONP) with dopamine-modified HA. These nanoparticles have a hydrophilic exterior and a hydrophobic interior where the chemotherapeutic homocamptothecin is encapsulated [56]. The biopotential of this process was investigated in both laboratory and in the live cells. Increased uptake of nanoparticles by tumor cells was observed by MRI when an external magnetic field was employed [56]. After the intravenous administration of the nano-vehicle in 3 mg/kg (relative to




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